Davinci isn't responding to any Loupedeck commands on Mac.

In the Main Page of the Color Profile press Activate. This should stay activated for your session. This should be the first thing to check.

Check your accessibility window to make sure you have allowed Loupedeck to control the computer.

Check to make sure your Keyboard Maestro engine is running. In Keyboard Maestro the File menu should read "Quit Engine" indicating it is currently running.

Double check the SideshowFX Color Panel script is enabled in Keyboard Maestro.