There are some instances on Mac where the Loupedeck device will not communicate with your application. No commands will work.
On Sonoma systems and older, check your System Settings/Privacy & Security/Automation panel. Scroll down to LogiPluginService and ensure these are checked (Capture One may not be available).
On Sequioa and M1 systems you can locate these settings under Privacy & Security/Accessibility. Make sure Loupedeck and LogiPluginSerive are checked.